Neuropsypharmacology

Computer aided drug design or CADD involves using various software to design drug molecule as per required therapeutic efficacy and physicochemical factors . It is a main process used in drug discovery. It involves study of 1.QSAR 2.Molecular Field rotation 3.Pharmacophore modeling 4.Docking 5.Target based drug designing 6.Proteonomics 5.Homology studies Etc Common softwares involved 1.Zinc database 2.Swiss Adme Swiss docking Swiss target prediction 3.MOPAC for QSAR 4.Marvin sketch 5.BLAST Etc

1. DHEA is a steroid hormone not found in food but popularly given as dietary supplement. 2.DHEA and its  sulfate  are  sex hormones  produced  in abundance  mainly  by the  adrenal  glands,  gonads,  and brain. It  has  its  production peak  between  25 and 35  years  of age and subsequent  decline  .  At  70 years  of age,  the  production of  these  hormones  is  between  10 and 20%  of what was  produced  during the  peak  phase  .  An indirect precursor of the  major adrenal  hormones,  DHEA  has  been linked to  a  number of benefits  to  the  human  organism,  including rejuvenation capacity,  cognitive  enhancement,  quality  of life,  sexual  function and mood 3. DHEA found to be widely used in depression...

Main topics discussed 1. machine learning to be used in clinical trial . 2 neural health systems helps translating patient information for medical history and other databases. 3.AI bots to be used in labs , acadics, technology, research and improving patient health. 4.Skyrlzi. To be used for psoriasis. 5.Major disease lymphoblastic hemophilia to be treated by himlibra 6. Almost 40drugs are poor water soluble.Mathew lam suggest new oral dosage form to increase bioavailability Liquipellet 7.GSK going good in growth in market , AstraZeneca sustained 8.PCNs helps to to find new solutions to major disease like heart failure . 9.Germany to lead bio similar production 10.gene editing found promising in many diseases like Huntington, cystic fibrosis, hiv

Aging, a complex process accompanied with the decline of multiple physiological, cellular and molecular functions, is associated with neurodegenerative diseases . >> Numerous evidences show that aging undergoes significant changes in chromatin structure, which indicates that gene expression alteration is one of the potential mechanisms  of aging . Numerous genes have been identified in aging brain of different models.Therefore, identification of key genes and pathways occurred in aging brain would reap huge fruits for understanding the mechanisms of aging. >>Its universally acknowledged that SAMP8 mouse is extensively used as a model of  aging-associated neurodegeneration  Accumulating evidence suggests that hippocampus or cerebral cortex regions were changed in normal aging process  and numerous DEGs have been examined in SAMP8 mice by different investigators. However, the functionally important genes and key pathways have not been revealed. I mport...

Hi, 1.ScFv therapy serves as a powerful and potential therapeu-tic tool in neurodegenerative diseases that are particularly associated with the accumulation of misfolded protein ag-gregates, such as Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD) 2.sin-gle-chain fragment variable antibodies (scFvs) to target the pathological protein aggregates, such as amyloid-beta (Aβ) peptides, α-synuclein (α-syn) and Huntingtin (Htt). 3.Pros  of scFvs a.)maintain the antigen-binding activity, affinity and specificity of full-sized antibodies. b)Since scFv is smaller in size, it permits better penetra-tion for tissues that are hardly or inaccessible to conventional monoclonal antibodies . c.)it can de-grade easily in human body, which leads to shorter half-lives and promotes rapid elimination from bloodstream d)scFvs which lack FC fragment also show minimised immunogenicity as a cellular immune response is commonly triggered...

How neuroplasticity is affected by physical exercise? Newborn neurons are primarily produced in two neurogenic zones in the adult brain: the subgranular zone (SGZ) of the DG in the hippocampus and the subventricular zone.About 700 newborn neurons are estimated to be added to a unilateral hippocampus in human each day. 1.Running reverses the stress-induced impairments to learning and memory, as well as reduces depression-like behaviors, to-gether with the restored hippocampal BDNF level and re-duced GR expression. 2.physical exercise - - secretes Neurotrophic factors -activate Noradrenaline neurons and Na metabolite -secretes serotonin -modifying the adaptive response of HPA axis to stress. 3.Exerkines are used as APIs to cause effects by exercise .Exerkines are peptides, nucleic acids and metabolites re-leased following exercise from skeletal muscles (myokines) or other organs/tissues such as liver (hepatokines), ligaments and adipose tissue (adipokines). The main points: Th...