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How DHEA used in depression

1.DHEA is a steroid hormone not found in food but popularly given as dietary supplement.

2.DHEA and its  sulfate  are  sex hormones  produced  in abundance  mainly  by the  adrenal  glands,  gonads,  and brain. It  has  its  production peak  between  25 and 35  years  of age and subsequent  decline  .  At  70 years  of age,  the  production of  these  hormones  is  between  10 and 20%  of what was  produced  during the  peak  phase  .  An indirect precursor of the  major adrenal  hormones,  DHEA  has  been linked to  a  number of benefits  to  the  human  organism,  including rejuvenation capacity,  cognitive  enhancement,  quality  of life,  sexual  function and mood

3.DHEA found to be widely used in depression,anxiety,mood disorders,anorexia.

4.But it contradicted in autoimmune disease and healthy people.Show no effect on depression patient with fibromyalgia.

5.DHEA-S  level  appears  to  be  an  indicative  of the  depression severity  in  relation  to  depressive  symptoms, especially  to feelings  of guilt  and failure.

6.DHEA  side effects:
DHEA  that  indicate  that only mild  androgenic  effects  are  observed  in  some  subjects . ie hair loss, oil on skin
In women :changes in menstrual cycles, fatigue, voice deepning.

7.Conclusion:

DHEA  was  shown  to  be  more  effective  than  placebo in the  treatment  of depressive  symptoms  in  subjects  with  depression or bipolar  disorder  in  the  depressive  phase.  This improvement  occurred  simultaneously  with  the  increase  in the  DHEA  and DHEA-S  circulating levels.  No significant side  effects  were  observed  in  the  individuals  studied.  Thus,  it is  possible  to  suggest  that  DHEA should be  considered  as another  alternative in  the treatment  of  depression.  Comparative  studies  between DHEA  and other antidepressant agents should be  considered  to  assess  their clinical  utility compared to  other established drugs.

LIST  OF  ABBREVIATIONS DHEA  =  Dehydroepiandrosterone DHEA-S  =  Dehydroepiandrosterone  Sulfate
 
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