Neuropsypharmacology

Parkinson disorder: It is a disorder which shows tremor ,rigidity and hypokinesia in patient due to low dopamine or dysfunction of dopaminergic receptor and neuron.  It may induce undesired depression AMD anxiety which results in attempting suicide .There is increase in cases of suicides in PD hence it is necessory to know the reason , effects and factors affecting disorder. Ref an article paper from Bentham science publisher vol 6  Dec 2019 1. Anxiety disorders  are  present  in  2030%  of PD  patients  and include  generalized anxiety,  social phobias  and panic  attacks  .  PD  patients  may  also  experience  additional  symptoms,  including hallucinations  ,  psychosis  ,and impulse  control  disorder   which are  often dopaminergic  treatment-related. 2.The main  goal of  treatment in  the prevention of suicide...

Major new medicinal drugs to treat depression :  1.Onion ( Allium cepa) -Quercetin glycosides  -MAO inhibitor 2.Green tea -polyphenols, catechins -regulate HPA axis activity 3.Clove -Kaempferol -MAO inhibitor 4.Lemon - apigenin ,essential oil, flavanoid - elevate platelet Adenyl cylase activity ,Activate serotonergic and dopanergic activity ,   5.Coriander  -  querectin -MAO inhibitor Other: 6. Crocus sativus .L 7.Zingiber officinale Rosco - phenolic constituents shogaol  -The alcoholic extract of the ginger at a dose of 300 mg/kg is found to be effective nearly similar to standard drug fluoxetine in FST. 8. Glycirrhiza glabra -flavonoids such as  liquiritin and isoliquiritin (at doses of 10, 20 and 40 mg/kg) in licorice have been reported to exhibit an antidepres- sant activity in mice models 9 .Lavendula officinalis ( lavender) - These phytochemicals are estimated  to be responsible for the sedative activity of the plant via γ-aminobutiric acid...

Major points in pharma times Oct 19 1.Stephan and James Huang to develop vaccines for cancer. It works by mRNA encoding for protein that neutralize cancer cells. 2. Lonsurf(triflurodine) to treat gastric cancer. ROCHE's Tensertiq(atezolizumab) to treat metastatic lung cancer. 3.Novartis's Ofatumumam more effective than Sanofi's Aufagio to treat multiple sclerosis. 4UK uses biosimilar medicines , saves £200 5.Statins to be prescribed by pharmacist . Main points in pharmacy times: Oct19 Drug therapy of choice to treat inflammation -biological DMARDS (tissue necrotic factor blocker)::subcutaneous olimumab -convention DMARDS :methotrexate -Tcell costimulation modulator -Non biological DMARDs  * Disease-modifying antirheumatic drugs ( DMARDs ) are a group of medications commonly used in people with rheumatoid arthritis. Some of these drugs are also used in treating other conditions such as ankylosing spondylitis, psoriatic arthritis, and systemic lupus erythematosus.

Computer aided drug design or CADD involves using various software to design drug molecule as per required therapeutic efficacy and physicochemical factors . It is a main process used in drug discovery. It involves study of 1.QSAR 2.Molecular Field rotation 3.Pharmacophore modeling 4.Docking 5.Target based drug designing 6.Proteonomics 5.Homology studies Etc Common softwares involved 1.Zinc database 2.Swiss Adme Swiss docking Swiss target prediction 3.MOPAC for QSAR 4.Marvin sketch 5.BLAST Etc

1. DHEA is a steroid hormone not found in food but popularly given as dietary supplement. 2.DHEA and its  sulfate  are  sex hormones  produced  in abundance  mainly  by the  adrenal  glands,  gonads,  and brain. It  has  its  production peak  between  25 and 35  years  of age and subsequent  decline  .  At  70 years  of age,  the  production of  these  hormones  is  between  10 and 20%  of what was  produced  during the  peak  phase  .  An indirect precursor of the  major adrenal  hormones,  DHEA  has  been linked to  a  number of benefits  to  the  human  organism,  including rejuvenation capacity,  cognitive  enhancement,  quality  of life,  sexual  function and mood 3. DHEA found to be widely used in depression...

Main topics discussed 1. machine learning to be used in clinical trial . 2 neural health systems helps translating patient information for medical history and other databases. 3.AI bots to be used in labs , acadics, technology, research and improving patient health. 4.Skyrlzi. To be used for psoriasis. 5.Major disease lymphoblastic hemophilia to be treated by himlibra 6. Almost 40drugs are poor water soluble.Mathew lam suggest new oral dosage form to increase bioavailability Liquipellet 7.GSK going good in growth in market , AstraZeneca sustained 8.PCNs helps to to find new solutions to major disease like heart failure . 9.Germany to lead bio similar production 10.gene editing found promising in many diseases like Huntington, cystic fibrosis, hiv

Aging, a complex process accompanied with the decline of multiple physiological, cellular and molecular functions, is associated with neurodegenerative diseases . >> Numerous evidences show that aging undergoes significant changes in chromatin structure, which indicates that gene expression alteration is one of the potential mechanisms  of aging . Numerous genes have been identified in aging brain of different models.Therefore, identification of key genes and pathways occurred in aging brain would reap huge fruits for understanding the mechanisms of aging. >>Its universally acknowledged that SAMP8 mouse is extensively used as a model of  aging-associated neurodegeneration  Accumulating evidence suggests that hippocampus or cerebral cortex regions were changed in normal aging process  and numerous DEGs have been examined in SAMP8 mice by different investigators. However, the functionally important genes and key pathways have not been revealed. I mport...