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new medicinal drugs in depression

Major new medicinal drugs to treat depression : 

1.Onion (Allium cepa)
-Quercetin glycosides 
-MAO inhibitor

2.Green tea
-polyphenols, catechins
-regulate HPA axis activity

3.Clove
-Kaempferol
-MAO inhibitor

4.Lemon
-apigenin,essential oil, flavanoid
-elevate platelet Adenyl cylase activity,Activate serotonergic and dopanergic activity , 

5.Coriander 
- querectin
-MAO inhibitor

Other:
6.Crocus sativus .L
7.Zingiber officinale Rosco
-phenolic constituents shogaol 
-The alcoholic extract of the ginger at a dose of 300 mg/kg is found to be effective nearly similar to standard drug fluoxetine in FST.

8. Glycirrhiza glabra
-flavonoids such as liquiritin and isoliquiritin (at doses of 10, 20 and 40 mg/kg)in licorice have been reported to exhibit an antidepres-
sant activity in mice models

9 .Lavendula officinalis ( lavender)
-These phytochemicals are estimated 
to be responsible for the sedative activity of the plant via γ-aminobutiric acid (GABA) modulation .
-antidepressant-like activity of lavender (200 and 400 mg/kg) may depend on its lipophilic components (essential oils and its major constituent linalool) or nonvolatile constituents (hy-droxycinnamic acids and flavone glycosides, apigenin,and rosmarinic acid)

10.Winthania somnifera (ashwagandha)
-glycowithanolides exhibited a serious antidepressant activity 
at the doses of 20 and 50 mg/kg via GABA-mimetic effect.

11.Melissa officinalis L.
-Rosmarinic acid, caffeic acid, quercitrin, and luteolin derivative compounds may underlie this effect

12 Rosmarinus officinalis L.(rosemary)
-polyphenols, such as carnosic acid, rosmarinic acid, betulinic acid, a terpenoid oxide 1,8-cineole, or triterpenoid ursolic acid .

13.Vanilla planifolia
-vanillin’s antioxidant property or agonistic action on α2adrenergic or opioid receptors 

14.Passiflora incarnata L. & Passiflora foetida L.
- the flavonoidal compounds interacting with adrenergic and serotonergic systems and harmaline alkaloids acting MAO inhibitors are thought to be responsible for the activity.
-(apigenin, vitexin, isovitexin, and kaempferol)

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