Skip to main content

new medicinal drugs in depression

Major new medicinal drugs to treat depression : 

1.Onion (Allium cepa)
-Quercetin glycosides 
-MAO inhibitor

2.Green tea
-polyphenols, catechins
-regulate HPA axis activity

3.Clove
-Kaempferol
-MAO inhibitor

4.Lemon
-apigenin,essential oil, flavanoid
-elevate platelet Adenyl cylase activity,Activate serotonergic and dopanergic activity , 

5.Coriander 
- querectin
-MAO inhibitor

Other:
6.Crocus sativus .L
7.Zingiber officinale Rosco
-phenolic constituents shogaol 
-The alcoholic extract of the ginger at a dose of 300 mg/kg is found to be effective nearly similar to standard drug fluoxetine in FST.

8. Glycirrhiza glabra
-flavonoids such as liquiritin and isoliquiritin (at doses of 10, 20 and 40 mg/kg)in licorice have been reported to exhibit an antidepres-
sant activity in mice models

9 .Lavendula officinalis ( lavender)
-These phytochemicals are estimated 
to be responsible for the sedative activity of the plant via γ-aminobutiric acid (GABA) modulation .
-antidepressant-like activity of lavender (200 and 400 mg/kg) may depend on its lipophilic components (essential oils and its major constituent linalool) or nonvolatile constituents (hy-droxycinnamic acids and flavone glycosides, apigenin,and rosmarinic acid)

10.Winthania somnifera (ashwagandha)
-glycowithanolides exhibited a serious antidepressant activity 
at the doses of 20 and 50 mg/kg via GABA-mimetic effect.

11.Melissa officinalis L.
-Rosmarinic acid, caffeic acid, quercitrin, and luteolin derivative compounds may underlie this effect

12 Rosmarinus officinalis L.(rosemary)
-polyphenols, such as carnosic acid, rosmarinic acid, betulinic acid, a terpenoid oxide 1,8-cineole, or triterpenoid ursolic acid .

13.Vanilla planifolia
-vanillin’s antioxidant property or agonistic action on α2adrenergic or opioid receptors 

14.Passiflora incarnata L. & Passiflora foetida L.
- the flavonoidal compounds interacting with adrenergic and serotonergic systems and harmaline alkaloids acting MAO inhibitors are thought to be responsible for the activity.
-(apigenin, vitexin, isovitexin, and kaempferol)

Comments

Post a Comment

Popular posts from this blog

review lithium as mood stabilizer

1.Lithium as a mood stabilizer has been used as the standard pharmacological treatment for Bipolar Disorder (BD)   2.Recent studies have also shown that it has the potential for the treatment of many other neurodegenerative disorders, including Alzheimer’s, Parkinson’s and Huntington’s disease, through its neurotrophic, neuroprotective, antioxidant and anti-inflammatory actions. -- Therefore, exploring its pharmacokinetic features and designing better lithium preparations are becoming important research topics.  ---Lithium is rapidly and completely absorbed from the gastrointestinal tract after oral administration. Its level is initially highest in serum and then is evidently redistributed to various tissue compartments. It is not metabolized and over 95% of lithium is excreted unchanged through the kidney, but different lithium preparations may have different pharmacokinetic features. Lithium has a narrow therapeutic window limited by various adverse effects, but some no...
Post a Comment
Read more

Brain connectivity improves human aesthetic responses to music

Brain connectivity improves human aesthetic responses to music Abstract: 1. white matter connectivity between sensory processing areas in the superior temporal gyrus and emotional and social processing areas in the insula and medial prefrontal cortex explains individual differences in reward sensitivity to music. 2.  findings provide the first evidence for a neural basis of individual differences in sensory access to the reward system, and suggest that social–emotional communication through the auditory channel may offer an evolutionary basis for music making as an aesthetically rewarding function in humans. 3.carried out by -- Using a combination of survey data, behavioral and psychophysiological measures and diffusion tensor imaging, Conclusion: Results from diffusion tensor imaging show that white matter connectivity between auditory perceptual regions (pSTG) and regions of the brain important for emo- tional and social processing (aIns, mPFC) reflect individual diffe...
Post a Comment
Read more

Drug toxicity of psychotropic drugs

Drug toxicity of psychotropic drugs. Drug toxicity is the development of severe, drug-related complications, which may require premature drug withdrawal or dose reduction. 1. acute toxicity is  highest in.                  antidepressants  lower in neuroleptics   very low in anxiolytics. 2. major problems stem  Anxiolytic ---misuse and overuse. neuroleptics --- tardive dyskinesia is a serious threat to longterm therapy.   antidepressants ---low therapeutic index and a resulting high incidence of severe and fatal poisoning cases, both intentional and accidental. 3.Poisoning death rates per million prescriptions were about 10 times higher for tricyclic antidepressants (TCAs) than for selective serotonin reuptake inhibitors (SSRIs), England and Wales, 1993-2004 4 .Psychotropic drugs with hepatotoxic potential can be classified based on their intended use:  1) antipsychoticsneuroleptics including phenothiazine...
Post a Comment
Read more