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Can drugs cause hibernation ?

Can a drug hibernate you?

1. What is actually hibernation state?
--Hibernation is identified by a prolonged state of energy conservation, termed torpor, that allows heterothermic mammals to tolerate the limited resource availability encountered in extreme environments .
Animal studies:
In hypothalamus , a particular group of neurons controls all metabolic activity. When it was blocked...
--mice began to enter torpor, the team focused on a gene called Fos -- previously shown by the Greenberg lab to be expressed in active neurons. Labeling the protein product of the Fos gene allowed them to identify which neurons are activated during the transition to torpor throughout the entire brain

--Studying torpor in mice helps us understand how this fascinating feature of warm-blooded animals might be manipulated through neural processes.confirm that these neurons are critical for torpor, the researchers used a separate virus-based tool to silence the activity of avMLPA-Vglut2 neurons.

This imply to humans after further research.
However ,in humans even a slight fldrop in body T. Causes hypothermia which is fatal.
Hibernation is induced by chemical compounds such as H2S and 5′-AMP, but there are con's.


2.Do drugs has anything to do with .
Scientists-
*targeted activation of the central A1AR combined with a lower Ta would provide a means of managing core body temperature (Tb) below 37 °C for therapeutic purposes.
*systemic delivery of the A1AR agonist 6N-cyclohexyladenosine (CHA) with 8-(p-sulfophenyl) theophylline (8-SPT), a nonspecific adenosine receptor antagonist that does not readily cross the blood–brain barrier.

Drug induced hibernation is used in safe reversible hypothermia without any cardiovascular side effects by lowering the shivering threshold at low ambient temperatures (Ta)
Activation of adenosine A1 receptors (A1ARs) in the central nervous system (CNS) induces hibernation in hibernating species and a hibernation-like state in rats, principally by attenuating thermogenesis.


ref: drug induced hibernation. Tulasi R. Jinka, Velva M. Combs, and Kelly L. Drew

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