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floating drug delivery for peptic ulcer

 Floating drug delivery for peptic ulcer
These systems float over the gastric contents because they have low density than gastric content. Suitable for those drug candidates which have a short half-life, irritant action on the stomach, or for those drugs which are absorbed from the stomach, and drugs that have less retention time in the stomach.
 There are mainly two types of FDDS, 
1.non-effervescent 
2.effervescent FDDS. 
Non-effervescent floating tablets are mainly composed of gel forming and 
swellable cellulose

Eg floating matrix tablet of Tolpison 
hydrochloride by the using hot melt granulation method 
(HMG) and found that the tablet prepared by this method 
shows the significant result of gastroretention

Advantages of FDDS
1. Floating dosage forms provide a long duration of time for the effective exposure of the drug in the stomach [41].
2. It provides local action of drug-like in case of antacids.
3. FDDS minimizes the irritational effects of drugs by slow drug release.
4. Best alternate for the drugs, which are absorbed at the stomach site.

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