Effect of lockdown on mental health . Both social isolation and loneliness are major risk factors for poor physical and mental health status through enhanced chronic inflammation; As chronic inflammation biomarkers, neutrophil-to-lymphocyte ratio (NLR) and the concentration of high-sensitivity C-reactive protein (CRP) were measured. Isolated-Lonely condition (i.e., being both socially isolated and feeling lonely) was associated with higher NLR among men (B = 0.141, 95%CI = −0.01 to 0.29). Interestingly, Nonisolated-Lonely condition (i.e., not socially isolated but feeling lonely) was associated with lower CRP among women . Solution: 1.Personal resilience, coping behaviours, and social support were identified as protective factors against loneliness. 2. Engage in social engagement activities via social media app. Engage in helping other or solving problems of other to lower get sense of satisfaction . 3.learn a new skill, make a new habit , extend your creativity by trying differen...